Research
Our research cluster applies a range of techniques such as MRI, MALDI mass spectrometry, fluorescent microscopy, electrophysiology and other biomolecular methodologies to examine the physiology of the eye, with a particular focus on the lens. Some areas of interest include how oxidative stress effects the lens, mechanisms of diabetic and age-related cataracts, and how water is transported and regulated throughout the lens. The aim of our research is to improve our understanding of the eye and its diseases, in hopes to develop health interventions for patients that are affected by various eye disorders.
Lens Physiology and Optics
Prof. Paul Donaldson‘s group are focused on determining how the interaction of a variety of ion channels and transporters contribute to the establishment and maintenance of the transparent and refractive properties of the lens.
Redox biology and Signalling in the Eye
Dr. Julie Lim‘s (Senior Lecturer) group aims to delay the onset of age-related eye diseases by identifying targeted strategies for minimising oxidative stress.
Biomolecular Imaging
Dr. Gus Grey‘s (Senior Research Fellow) group is focused on applying spatially resolved imaging technologies, such as MALDI imaging mass spectrometry and fluorescence microscopy, to investigate the molecular basis of ocular diseases and treatment of these diseases.
Oxidative Stress and Eye Disease
Dr. Renita Martis‘ (Research Fellow) interests lie in understanding the molecular mechanisms that contribute to the onset of age-related eye disease such as cataracts and retinal disease.
Aquaporin water channels in ocular lens physiology
Dr. Rosica Petrova‘s (Research Fellow) research looks into identifying the contributions of several members of the water channel family of proteins known as aquaporins (AQPs) in maintaining lens transparency.